Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome

作者：Goto Makoto^*; Sugimoto Kazunori; Hayashi Seigaku; Ogino Tetsuhito; Sugimoto Masanobu; Furuichi Yasuhiro; Matsuura Masaaki; Ishikawa Yuichi; Iwaki Egawa Sachiko; Watanabe Yasuhiro

来源：Experimental Gerontology, 2012, 47(12): 936-939.

DOI：10.1016/j.exger.2012.08.010

• Aging
• Werner syndrome
• Inflammaging
• Inflammation
• hsCRP

Minor inflammation-driven aging (inflammaging) has been proposed to explain human aging mechanism. To study the inflammatory condition associated with normal human aging, highly sensitive CRP (hsCRP) was examined in the sera collected from 217 healthy Japanese individuals aged between 1 and 100 years and 41 mutation-proven Japanese Werner syndrome (WS) patients. The serum hsCRP was assayed by ELISA. The serum hsCRP level increased significantly (p%26lt;0.001) with normal aging from both sexes. The serum hsCRP was significantly elevated in WS (mean +/- SE: 11.0 +/- 1.6 mu g/ml) compared with age-matched normal population (1.3 +/- 0.3 mu g/ml, p%26lt;0.001) and normal elderly population ages between 71 and 100 years (4.2 +/- 0.7 mu g/ml, p%26lt;0.001). Both normal aging and WS were associated with minor inflammation that can be evaluated by serum hsCRP. WS may be a good candidate to study inflammaging.

• 出版日期2012-12