Fucoidan Isolated from Laminaria angustata var. longissima Induced Macrophage Activation

作者：Teruya Takeshi; Takeda Shinji; Tamaki Yukihiro; Tako Masakuni^*

来源：Bioscience Biotechnology and Biochemistry, 2010, 74(9): 1960-1962.

DOI：10.1271/bbb.100294

• Laminaria angustata var. longissima
• fucoidan
• macrophage activation

We investigated macrophage activation by fucoidan from Laminaria angustata var. longissima in a murine macrophage cell line, RAW 264.7. The ratio of the chemical composition of the fucoidan was L-fucose: D-galactose:D-glucose:D-xylose:uronic acid:sulfate = 1.00:0.54:0.08:0.08:0.64:0.87. The fucoidan induced production of nitric oxide, tumor necrosis factor-alpha, and interleukin-6 in RAW 264.7 cells. These results indicate that the fucoidan induced macrophage activation.

• 出版日期2010-9