Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease

作者：Nagao Masahiro^*; Hayashi Hideaki

来源：Journal of the Neurological Sciences, 2009, 281(1-2): 51-54.

DOI：10.1016/j.jns.2009.02.375

• Apoptosis
• JNK
• Serine/treonine kinase
• Calcium sensor protein
• ER stress
• Synucleopathy
• Multiple system atrophy
• Glial cytoplasmic inclusion

The expression of hippocalcin, a calcium-sensor protein of the recoverin family, and mixed lineage kinase 2 (MLK2) in Lewy bodies (LBs) Was immunohistochemically examined in patients with Parkinson's disease (PD). Hippocalcin and MLK2 were colocalized in the halo, of LBs, and neither protein was detected in normal pigmented neurons. Since hippocalcin binds to the C-terminal region of MLK2 [Nagata K., Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T et A., The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J 1998; 17:149-1588.], it may constitutively activate MLK2. Both hippocalcin and MLK2 may be associated with the pathogenesis of PD.

• 出版日期2009-6-15