A novel hepatoprotective saponin from Celosia cristata L.

作者：Wang Yan; Lou Ziyang; Wu Qing Bin; Guo Mei Li^*

来源：Fitoterapia, 2010, 81(8): 1246-1252.

DOI：10.1016/j.fitote.2010.08.011

• Amaranthaceae
• Celosia cristata L.
• Cristatain
• Hepatoprotective effect

A new saponin, cristatain (1), together with four other saponins, celosin A (2), celosin B (3), celosin C (4) and celosin D (5) were isolated from the seeds of Celosia cristata L. (Amaranthaceae). Their structures were established by chemical and spectroscopic analyses. For the first time, the saponins were found in C. cristata L In addition, compound 1 exhibited significant hepatoprotective effect on carbon tetrachloride (CCl(4))- and N,N-dimethylformamide (DMF)-induced hepatotoxicity in mice, which were evidenced by significant decreases in the values of asparate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) of serum and histopathological examinations compared to controls.

• 出版日期2010-12
• 单位中国人民解放军第二军医大学