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结肠黏膜低度炎症对小鼠结肠PAR-2活化和内脏感觉过敏的诱发作用
刘玮
王承党
世界华人消化杂志, 2010, (32): 3413-3419
Summary
目的:探讨结肠蛋白酶激活受体(PAR-2)活化与结肠黏膜低度炎症时小鼠内脏感觉过敏的关系.方法:36只C57B/6小鼠随机分为2组.A组(对照组),18只,给予无菌蒸馏水自由饮用;慢性低度炎症(LGI)组(S组),18只,1.5%葡聚糖硫酸钠(DSS)溶液自由饮用5d,续以无菌蒸馏水10d.第15天时观察病理学改变、测定腹壁肌电、免疫组织化学染色腰膨大部(L6-S1)脊髓背角SP、CGRP表达和结肠组织PAR-2表达.结果:第15天时,S组(LGI组)结肠黏膜炎症评分为1.500±0.926.结肠内压力为15mmHg时,S组的腹壁肌电幅值与A组比较无统计学意义(27.958μV±1.660μV...
Keywords
肠易激综合征; 结肠黏膜低度炎症; 内脏感觉; 蛋白酶活化受体-2; 结肠扩张; P物质; 降钙素基因相关肽 Irritable bowel syndrome; Low-grade mucosal inflammation; Visceral sensitivity; Protease-activated receptor-2; Colorectal distension; Substance P; Calcitonin gene-related peptide
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