Association of the manganese superoxide dismutase gene Ala-9Val polymorphism with clinical phenotypes and tardive dyskinesia in schizophrenic patients

作者：Liu Hong; Wang Cui; Chen Pin Hong; Zhang Ben Shu; Zheng You Lan; Zhang Chong Xi; Meng Hua Qing; Wang Yu; Chen Da Chun; Xiu Mei Hong; Kosten Thomas R^*; Zhang Xiang Yang

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010, 34(4): 692-696.

DOI：10.1016/j.pnpbp.2010.03.026

• Association
• Manganese superoxide dismutase
• Polymorphism
• Schizophrenia
• Tardive dyskinesia

Objective: Several recent studies that have investigated the genetic association between the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) and tardive dyskinesia (TD) have produced conflicting results. This study was to investigate whether this SNP was associated with clinical phenotypes and antipsychotic-induced tardive dyskinesia (TD) in schizophrenia in a genetically homogeneous Han Chinese inpatient population.
Methods: Genotyping was performed for the MnSOD gene Ala-9Val SNP in Chinese schizophrenia patients with (n = 176) and without TD (n = 346). The severity of TD was assessed using the abnormal involuntary movement scale (AIMS), and psychopathology using the Positive and Negative Syndrome Scale (PANSS).
Results: The frequencies of genotypes and alleles did not differ significantly between schizophrenic patients with and without TO (both p>0.05). Also, there was no significant difference in the AIMS total score between the Val/Val and Ala allele carrier groups (p>0.05). However, the PANSS negative symptom subscore was significantly higher in patients with Val/Val genotype (21.8 +/- 7.3) than those with Ala alleles (20.1 +/- 7.7) (t = 2.32, p = 0.03).
Conclusion: While the MnSOD gene Ala-9Val polymorphism did not play a major role in the susceptibility to TD in schizophrenic patients, it might be associated with negative symptoms of schizophrenia.

• 出版日期2010-5-30
• 单位山东大学; 重庆医科大学; 长治医学院; 北京回龙观医院; 吉林农业大学; 天津医科大学