A new photocrosslinkable hydrogel based on a derivative of polyaspartic acid for the controlled release of ketoprofen

作者：Cao, Hui; Ma, Xiaoyan; Sun, Shaohua; Su, Haijia; Tan, Tianwei^*

来源：Polymer Bulletin, 2010, 64(6): 623-632.

DOI：10.1007/s00289-009-0215-z

• Polyaspartic acid
• Hydrogel
• Photocrosslinking
• Drug release
• Ketoprofen

A novel photocrosslinkable and pH-sensitive hydrogel used for drug delivery was developed based on polyaspartic acid. Polysuccinimide (PSI) was modified by hydrazine and acryloyl chloride. The unreacted imide rings of PSI were hydrolyzed. Hydrogels were formed by photocrosslinking without any crosslinker or photoinitiator. Products were characterized by FT-IR and solid-state (CNMR)-C-13 analysis. The swelling behaviors of hydrogel in various pH values were studied. Ketoprofen (KP) was chosen as a model drug. Two drug loading methods were compared. The release kinetics of KP was evaluated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) at 37 A degrees C. The results showed that drug-loaded hydrogels were resistant to SGF, and hence they could be useful for oral drug delivery. There would be a wide range of applications for controlled drug delivering system.

• 出版日期2010-4
• 单位北京化工大学