Diabetes Mellitus and Risk of Stroke and Its Subtypes Among Japanese The Japan Public Health Center Study

作者：Cui Renzhe; Iso Hiroyasu^*; Yamagishi Kazumasa; Saito Isao; Kokubo Yoshihiro; Inoue Manami; Tsugane Shoichiro

来源：Stroke, 2011, 42(9): 2611-2614.

DOI：10.1161/STROKEAHA.111.614313

• diabetes
• epidemiology
• follow-up study
• stroke

Background and Purpose-Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians.
Methods-A survey was conducted of a total of 13 129 men and 22 528 women aged 40 to 69 years at baseline. During the median 12.0-year follow-up, there were 526 incidences of ischemic strokes (259 lacunar infarctions, 91 large-artery occlusive, and 140 embolic infarctions).
Results-The risk of ischemic stroke for both sexes was approximately 2 to 4 times higher for diabetic subjects than for those with normal glucose levels. Significant excess risks of lacunar and embolic infarction for both sexes and of large-artery occlusive infarctions for women were also observed in diabetic subjects. Diabetes mellitus was not associated with risk of intraparenchymal or subarachnoid hemorrhage for either sex.
Conclusions-Diabetes mellitus is a significant risk factor for ischemic stroke and all subtypes of ischemic stroke for middle-aged Japanese. (Stroke. 2011;42:2611-2614.)

• 出版日期2011-9