Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

作者：Stephens Matthew D; Hubble Veroncia B; Ernst Robert K; van Hoek Monique L; Melander Roberta J; Cavanagh John; Melander Christian^*

来源：Medchemcomm, 2016, 7(1): 128-131.

DOI：10.1039/c5md00353a

A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containing an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.

• 出版日期2016