Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in borderline personality disorder

作者：Tadic Andre^*; Elsaesser Amelie; Victor Anja; von Cube Robert; Baskaya Oemuer; Wagner Stefanie; Lieb Klaus; Hoeppner Wolfgang; Dahmen Norbert

来源：Journal of Neural Transmission, 2009, 116(9): 1185-1188.

DOI：10.1007/s00702-009-0264-3

• Borderline personality disorder
• Genetics
• HTR1B
• BDNF
• Gene-gene interaction

The purpose of this study was to test for association between Borderline personality disorder (BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. We genotyped four HTR1B and the functional BDNF G196A marker in 161 Caucasian BPD patients and 156 healthy controls. There were no significant differences between groups in genotype or haplotype distribution of HTR1B markers or in genotype distribution of the BDNF marker. Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients.

• 出版日期2009-9
• 单位河北医科大学