Recommendations for Diagnostics and Therapy of Children with Cancer Presenting with Fever and Neutropenia - Comparison of Two Current Guidelines

作者：Lehrnbecher Thomas^*; Groll Andreas; Agyeman Philipp; Ammann Roland A; Attarbaschi Andishe; Behrends Uta; Berger Christoph; Hamprecht Axel; Hufnagel Markus; Laws Hans Juergen; Scheler Max; Temme Christian; Vieth Simon; Simon Arne

来源：Klinische Padiatrie, 2018, 230(3): 115-121.

DOI：10.1055/s-0044-101953

• Child
• cancer
• neutropenia
• fever
• antimicrobial therapy

Immunocompromised children and adolescents receiving treatment for cancer have a considerably increased risk for infection. Neutropenia is the most important single risk factor for infectious complications, and fever in neutropenia is considered as an emergency. Whereas guidelines for the management of fever in neutropenic adults have been established for decades, specific pediatric guidelines have not been developed until recently. As children differ in many aspects from adults such as in the underlying malignancy or in the availability and dosing of antimicrobial compounds, guidelines for pediatric patients are important. This article reviews similarities and differences between the recently published German interdisciplinary guideline of the German Societies of Pediatric Infectious Diseases and Pediatric Oncology and Hematology and a guideline developed by a panel of international experts for the management of fever in neutropenia in children and adolescents.

• 出版日期2018-5