Multicenter randomized clinical trial of retinal photocoagulation for preproliferative diabetic retinopathy

作者：Sato Yukihiro^*; Kojimahara Noriko; Kitano Shigehiko; Kato Satoshi; Ando Noburo; Yamaguchi Naohito; Hori Sadao

来源：Japanese Journal of Ophthalmology, 2012, 56(1): 52-59.

DOI：10.1007/s10384-011-0095-2

• Preproliferative diabetic retinopathy
• Photocoagulation
• Nonperfusion areas
• Randomized clinical trials

To evaluate the effectiveness of selective photocoagulation (S-PC) for nonperfusion areas (NPA) in preproliferative diabetic retinopathy (PPDR). %26lt;br%26gt;A multicenter randomized controlled clinical trial of 69 patients with PPDR showing NPA comparable to or larger than those on reference photographs. %26lt;br%26gt;The patients were assigned to 2 groups; one was treated with S-PC (PC group: 32 patients), while the other did not receive S-PS (non-PC group: 37 patients). In the non-PC group, panretinal photocoagulation (PRP) was performed whenever proliferative diabetic retinopathy (PDR) developed. In the PC group, S-PC of the NPA was performed followed by additional coagulation whenever the NPA extended, and PRP was performed whenever PDR developed. The primary outcome was the development of PDR. %26lt;br%26gt;During the entire course, PDR developed in 18 (26%) of the 69 patients. The incidence was significantly higher in the non-PC group than in the PC group. Comparison of the visual acuity at the time of registration and after 36 months showed no significant differences between the two groups. %26lt;br%26gt;S-PC for NPA in PPDR is effective at preventing PDR development.

• 出版日期2012-1