A novel and highly efficient esterification process using triphenylphosphine oxide with oxalyl chloride

作者：Jia, Mingzhu; Jiang, Lixue; Niu, Fanfan; Zhang, Yu; Sun, Xiaoling^*

来源：Royal Society Open Science, 2018, 5(2): 171988.

DOI：10.1098/rsos.171988

• triphenylphosphine oxide
• coupling reagent
• oxalyl chloride
• esterification

Triphenylphosphine oxide (TPPO) and oxalyl chloride ((COCl)(2)) are used as novel and high-efficiency coupling reagents for the esterification of alcohols with carboxylic acids via the TPPO/(COCl)(2) system at room temperature for 1 h. The reaction represents the first TPPO-promoted esterification under mild and neutral conditions with excellent yields. Furthermore, we proposed a plausible mechanism with the help of P-31 NMR spectroscopy.

• 出版日期2018-2
• 单位上海应用技术大学