Detection by microneutralization of antibodies against avian influenza virus in an endemic avian influenza region

作者：Apisarnthanarak A^*; Puthavathana P; Mundy L M

来源：Clinical Microbiology and Infection, 2010, 16(9): 1354-1357.

DOI：10.1111/j.1469-0691.2010.03148.x

• Anti-H5
• avian influenza
• low titre
• microneutralization antibody
• poultry workers
• Thailand

P>Detection by microneutralization of low-titre antibodies (anti-H5 micro-NT titre < 1 : 80) against avian influenza virus (H5N1) is usually taken to be a false-positive result. In this prospective study of 242 intensive-care unit patients admitted for severe community-acquired pneumonia, the prevalence of low-titre anti-H5 micro-NT was 2.4%. Prior exposure to poultry was the sole independent risk factor for these low-titre antibodies (adjusted OR 42.41; 95% CI 22.45-64.51; p < 0.001). We suggest that low anti-H5 micro-NT titres be interpreted in conjunction with plausible poultry, environmental and human exposure to H5N1.

• 出版日期2010-9