Decalmodulation of Ca(v)1 channels by CaBPs

作者：Hardie Jason; Lee Amy^*

来源：Channels, 2016, 10(1): 33-37.

DOI：10.1080/19336950.2015.1051273

• Ca2+ channel
• calmodulin
• inactivation
• L-type

Ca2+-dependent inactivation (CDI) is a negative feedback regulation of voltage-gated Ca(v)1 and Ca(v)2 channels that is mediated by the Ca2+ sensing protein, calmodulin (CaM), binding to the pore-forming Ca-v (1) subunit. David Yue and his colleagues made seminal contributions to our understanding of this process, as well as factors that regulate CDI. Important in this regard are members of a family of Ca2+ binding proteins (CaBPs) that are related to calmodulin. CaBPs are expressed mainly in neural tissues and can antagonize CaM-dependent CDI for Ca(v)1 L-type channels. This review will focus on the roles of CaBPs as Ca(v)1-interacting proteins, and the significance of these interactions for vision, hearing, and neuronal Ca2+ signaling events.

• 出版日期2016-1-2