科研之友
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摘要
A novel Fe-NHC catalytic system allows the alkyl-alkyl cross-coupling reaction of alkyl halides and alkylmagnesium reagents has been developed. To our knowledge, this is the first Fe-catalysed Kumada-type coupling for the formation of C(sp(3))-C(sp(3)) bonds in the presence of functional groups. The process takes place under mild conditions, avoiding the formation of beta-elimination products. Mechanistic studies suggest the intermediacy of Fe(I) complexes, formed by reduction with the Grignard reagent, as the active species.
- 出版日期2013
