Natural collagenic skeleton of marine sponges in pharmaceutics: Innovative biomaterial for topical drug delivery

作者：Langasco Rita; Cadeddu Barbara; Formato Marilena; Lepedda Antonio Junior; Cossu Massimo; Giunchedi Paolo; Pronzato Roberto; Rassu Giovanna; Manconi Renata^*; Gavini Elisabetta^*

来源：Materials Science & Engineering C-Materials for Biological Applications, 2017, 70: 710-720.

DOI：10.1016/j.msec.2016.09.041

• Porifera skeleton
• Bioactive-biomimetic material
• Glycosaminoglycan
• Alginate-based film
• Environmentally sustainable formulation
• Novel wound dressing

The growing interest in the use of recyclable and biodegradable natural materials has become a relevant topic in pharmaceutics. In this work, we suggest the use and valorization of natural homy skeleton of marine sponges (Porifera, Dictyoceratida) as bio-based dressing for topical drug delivery. Biomaterial characterization focusing on morpho-functional traits, swelling behavior, fluid uptake performances, glycosaminoglycans content and composition andmicrobiological quality assessment was carried out to investigate the collagenic skeletonproperties. After grinding and sieving processes, L-cysteine hydrochloride-loaded formulations were designed in form of powder or polymeric film by testing various drug concentrations and different drying parameters. Drug content SEM analyses and in vitro permeation studies were performed to test the suitability of skeleton-based formulations. To this respect, drying time and temperature are key parameters for skeleton-mediated drug crystallization. Consequently, this behavior seems to influence drug loading and permeation profiles of formulations. The high percentages of drug are found after absorption into sponge powder and in vitro permeation studies demonstrate that cysteine is released more slowly than the pure drug within 1 h. Such a system is attractive because it combines the known healing properties of cysteine with the advantageous potentials of the collagen/proteoglycan network, which can act as biocompatible carrier able to absorb the excess of the wound exudate while releasing the drug. Furthermore, due to its glycosaminoglycans content, natural sponge skeletal scaffold might act as bioactive-biomimetic carrier regulating the wound healing processes.

• 出版日期2017-1-1