Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity

作者：Saad Hosam A^*; Youssef Mohamed M; Mosselhi Mosselhi A

来源：Molecules, 2011, 16(6): 4937-4957.

DOI：10.3390/molecules16064937

• 1,2,4-triazinone
• thiadiazinone
• triazinone
• triazine carbonitrile
• microwave synthesis

Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl) vinyl]-1,2,4-triazin-5(4H)-one 1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-b][1,3,4] thiadiazinones, 1,3,4-thiadiazolo[2,3-c][1,2,4] triazinone and pyrazolo[5,1-c][1,2,4] triazine-7-carbonitrile, have been synthesized by treatment of 1 with bifunctional oxygen and halogen compounds, CS(2)/KOH and malononitrile via heterocyclization reactions, in addition to some uncondensed triazines. Structures of the products have been deduced from their elemental analysis and spectral data (IR, (1)H-NMR, (13)C-NMR). Select new synthesized compounds were screened as anticancer agents, with some showing activity as cytotoxic agents against different cancer cell lines.

• 出版日期2011-6