Novel thiosemicarbazones derivatives bearing aromatic iodine moiety: Design, synthesis and anti-malarial activity

作者：Duan L P; Zhang H B^*

来源：Arabian Journal of Chemistry, 2011, 4(2): 231-234.

DOI：10.1016/j.arabjc.2010.06.042

• Anti-malarials
• Thiosemicarbazone
• Aromatic iodide
• Plasmodium falciparum

A series of thiosemicarbazones of aromatic iodide derivatives were designed and synthesized. The structures of all the newly synthesized compounds had been identified by elemental analysis, (1)H NMR and (13)C NMR. Their biological activities were evaluated against Plasmodium falciparum. Among these compounds, at concentrations of 3, 9 and 27 mg/kg of mouse per day, 4e inhibited the growth of the malaria parasite in vivo test in mice with the respective percentages: 88.1%, 90.7% and 92.6%. The present work suggest that thiosemicarbazones of aromatic iodide may become a lead compound for anti-malaria medicine.

• 出版日期2011-4
• 单位中国疾病预防控制中心; 中国疾病预防控制中心寄生虫病预防控制所