Association of neutrophil/lymphocyte ratio with long-term mortality after ST elevation myocardial infarction treated with primary percutaneous coronary intervention

作者：Shen Xu hua; Chen Qi; Shi Yan; Li Hong wei^*

来源：Chinese Medical Journal, 2010, 123(23): 3438-3443.

DOI：10.3760/cma.j.issn.0366-6999.2010.23.012

• neutrophil/lymphocyte ratio
• primary percutaneous coronary intervention
• ST elevation myocardial infarction
• inflammation

Background Primary percutaneous coronary interventions (PCI) have been proposed as a novel superior management strategy in patients with ST elevation myocardial infarction (STEMI) This study tested the hypothesis that in the acute phase of myocardial infarction with ST-segment elevation, the neutrophil/lymphocyte (N/L) ratio is a predictor of long term prognosis
Methods We analyzed 551 consecutive STEM! patients treated with primary PCI at a single university center Patients were stratified according to quartiles of the mean neutrophil/lymphocyte ratio
Results Kaplan-Meier survival analysis showed a cumulative eight year survival of 94 2% in the first quartile, 92 0% in the second quartile, 91 3% in the third quartile, and 75 4% in the fourth quartile (P <0 001 by log rank) Relative to patients in the other three lower N/L ratio quartiles patients in the highest quartile were more than four times more likely to die during hospitalization (P <0 001) and during long-term follow up (P <0 001) By multivariate Cox regression analysis including baseline demographic, clinical, and angiographic covariables, the N/L ratio in the highest quartile remained an independent predictor of mortality (hazard ratio 2 38, 95% confidence interval (CI) 1 42 to 3 98, P=0 001)
Conclusion The neutrophil/lymphocyte ratio is a strong independent predictor of long term mortality after ST elevation myocardial infarction treated with very early revascularization

• 出版日期2010-12-5
• 单位首都医科大学