A retrospective study of deep sternal wound infections: clinical and microbiological characteristics, treatment, and risk factors for complications

作者：Chan Monica; Yusuf Erlangga^*; Giulieri Stefano; Perrottet Nancy; Von Segesser Ludwig; Borens Olivier; Trampuz Andrej

来源：Diagnostic Microbiology and Infectious Disease, 2016, 84(3): 261-265.

DOI：10.1016/j.diagmicrobio.2015.11.011

• Post-operative mediastinitis
• Sternal osteomyelitis
• Deep sternal wound infection
• Sternotomy
• Negative pressure wound therapy

Deep sternal wound infection (DSWI) is a feared complication following cardiac surgery. This study describes clinical, microbiological, and treatment outcomes of DSWI and determines risk factors for complications. Of 55 patients with DSWI, 66% were male and mean age was 68.2 years. Initial sternotomy was for coronary artery bypass graft in 49% of patients. Sternal debridement at mean 25.4 +/- 18.3 days showed monomicrobial (94%), mainly Gram-positive infection. Secondary sternal wound infection (SSWI) occurred in 31% of patients, was mostly polymicrobial (71%), and was predominantly due to Gram-negative bacilli. Risk factors for SSWI were at least 1 revision surgery (odds ratio [OR] 4.8 [95% confidence interval {CI} 1.0-22.4], P = 0.047), sternal closure by muscle flap (OR 4.6[1.3-16.8], P = 0.02), delayed sternal closure (mean 27 versus 14 days, P = 0.03), and use of vacuum-assisted closure device (100% versus 58%, P = 0.008). Hospital stay was significantly longer in patients with SSWI (69 days versus 48 days, P = 0.04).

• 出版日期2016-3