Antitumor dinuclear platinum(II) complexes derived from a novel chiral ligand

作者：Gao, Chuanzhu; Xu, Gang; Gou, Shaohua^*

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(21): 6386-6388.

DOI：10.1016/j.bmcl.2011.08.100

• 1R,2R-Diaminocyclohexane derivative
• Dinuclear platinum(II) complexes
• Cytotoxicity

A new chiral ligand, 2-(((1R,2R)-2-aminocyclohexyl) amino) acetic acid (HL), was designed and synthesized to prepare a series of novel dinuclear platinum(II) complexes with dicarboxylates or sulfate as bridges. The evaluation of these metal complexes in vitro cytotoxicity against human HCT-116, MCF-7 and HepG-2 cell lines were made. All compounds showed antitumor activity to HCT-116 and MCF-7. Particularly, compounds M3 and M5 not only exhibited better activity than carboplatin against MCF-7 and HepG-2, but also showed very close activity to oxaliplatin against HCT-116.

• 出版日期2011-11-1
• 单位东南大学