A multiscale model to evaluate the efficacy of anticancer therapies based on chimeric polypeptide nanoparticles

作者：Paiva L R; Martins M L

来源：Applied Physics Letters, 2011, 98(5): 053703.

DOI：10.1063/1.3551619

A multiscale model for tumor growth and its chemotherapy using conjugate nanoparticles is presented, and the corresponding therapeutic outcomes are evaluated. It is found that doxorubicin assembled into chimeric polypeptide nanoparticles cannot eradicate either vascularized primary tumors or avascular micrometastasis even administrated at loads close to their maximum tolerated doses. Furthermore, an effective and safety treatment demands for conjugate nanoparticles targeted to the malignant cells with much higher specificity and affinity than those currently observed in order to leave most of the normal tissues unaffected and to ensure a fast intracellular drug accumulation.

• 出版日期2011-1-31