A direct synthesis of 3-acyl-4-hydroxy-2-pyranone derivatives via palladium-catalyzed carbonylation of alpha-chloroketones. A cascade reaction involving acylketenes

作者：Perrone Serena; Caroli Antonio; Cannazza Giuseppe; Granito Catia; Salomone Antonio; Troisi Luigino^*

来源：Tetrahedron Letters, 2015, 56(21): 2773-2776.

DOI：10.1016/j.tetlet.2015.04.032

• Pd-catalysis
• Carbonylation
• alpha-Chloroketone
• 2-Pyranone
• Acylketene

A simple and direct method to obtain 3-acyl-4-hydroxy-2-pyranone derivatives by the palladium-catalyzed carbonylation of alpha-chloroketones has been described. The methodology can be applied to a variety of aromatic and aliphatic ketones to afford valuable products from both a synthetic and a biological point of view. A mechanistic hypothesis involving an acylketene intermediate has also been proposed.

• 出版日期2015-5-20