Alterations in Cardiac Mechanics Following Ultra-Endurance Exercise: Insights from Left and Right Ventricular Area-Deformation Loops

作者：Lord Rachel; George Keith; Somauroo John; Stembridge Mike; Jain Nikhil; Hoffman Martin D; Shave Rob; Haddad Francois; Ashley Euan; Jones Helen; Oxborough David^*

来源：Journal of the American Society of Echocardiography, 2016, 29(9): 879-+.

DOI：10.1016/j.echo.2016.05.004

• Echocardiography
• Endurance exercise
• Strain imaging
• Area-deformation loops
• Cardiac mechanics

Background: The aim of this study was to use novel area-deformation (epsilon) loops to interrogate the interaction between the right ventricular (RV) and left ventricular (LV) mechanics following a 100-mile endurance run.
Methods: Fifteen participants (mean body mass, 70.1 +/- 8.8 kg; mean age, 40 +/- 8 years) were recruited for the study. Echocardiography was performed before the race, after the race, and 6 hours into recovery. RV and LV area and longitudinal epsilon were assessed using standard and speckle-tracking echocardiography. Following cubic spline interpolation, these variables were obtained across the same cardiac cycle and used to derive area-epsilon loops.
Results: The RV area-epsilon loop demonstrated a rightward shift after the race, with increased RV area (from 26.0 to 27.1 cm(2)) and reduced peak RV epsilon (from -28.6% to -25.8%). The recovery RV area-epsilon loop was similar to the postrace loop. A leftward shift was observed in the LV area-epsilon loop after the race, secondary to reduced LV area (from 35.8 to 32.5 cm(2)) and reduced peak epsilon (from -18.3% to -16.6%). In recovery, LV epsilon values returned toward baseline.
Conclusions: A 100-mile ultramarathon resulted in a rightward shift in the RV area-epsilon loop as a result of RV dilatation. There was a concomitant leftward shift in the LV area-epsilon loop as a result of underfilling of the left ventricle. At 6 hours after exercise, there was a partial recovery of the left ventricle, while RV function remained depressed. It appears that changes in RV function do not have a serial impact on the left ventricle during recovery from ultra-endurance activity.

• 出版日期2016-9