Mir-196a-2 C > T polymorphism as a susceptibility factor for colorectal cancer

作者：Shi, Liang^*; Zhang, Chongyang; Zhao, Dongqiang; Liu, Kexia; Li, Tiejun; Tian, Hui

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(2): 2600-2606.

• mir-196a-2 C > T
• CRC
• polymorphism
• susceptibility

Objective: This study aimed to gain a better insight into the impact of the mir-196a-2 C>T polymorphism on the susceptibility to colorectal cancer (CRC). Methods: In a meta-analysis of 6 publications with a total of 1,754 cancer cases and 2,430 controls, we summarized the data on the associations between the studied mir-196a-2 C>T polymorphism and CRC risk and conducted subgroup analyses by ethnicity and control sources. Results: We found no overall association between the mir-196a-2 C>T polymorphism and CRC risk. But a significant association was found in the stratified analysis according to ethnicity among Asians (ORCC vs. TT = 1.22, 95% CI = 1.02-1.45, P-heterogeneity = 0.718; ORCC vs. TC + TT = 1.22, 95% CI = 1.04-1.44, P-heterogeneity = 0.590; ORallele C vs. allele T = 1.10, 95% CI = 1.01-1.20, P-heterogeneity = 0.726) rather than Caucasians. Conclusions: Our results suggested that there was no overall risk of CRC in relation to the mir-196a-2 C>T polymorphism. However, this polymorphism was associated with an increased risk in Asian populations.

• 出版日期2015
• 单位河北医科大学