Pioglitazone, PPARγ Agonist, Attenuates Experimental Autoimmune Neuritis

作者：Ramkalawan, Hhoonisha; Wang, Yu-Zhong; Hurbungs, Ameet; Yang, Yan-Fang; Tian, Fa-Fa; Zhou, Wen-Bin^*; Li, Jing; Yang, Huan; Xiao, Bo; Zhang, Wei

来源：Inflammation, 2012, 35(4): 1338-1347.

DOI：10.1007/s10753-012-9447-4

• pioglitazone
• PPAR gamma
• experimental autoimmune neuritis
• anti-inflammatory
• NF-kappa B

Recent advances demonstrate peroxisome proliferator-activated receptors gamma (PPAR gamma) agonist, pioglitazone, as an anti-inflammatory drug. We investigated the effect of pioglitazone on experimental autoimmune neuritis (EAN) rats. Pioglitazone was given once daily (10 mg/kg) by oral gavage feeding from day 1-24 (suppressive group) and day 11-24 (therapeutic group). Pioglitazone ameliorated the clinical score of EAN, decreased expression of TNF-alpha, IFN-gamma, and the activation of NF-kappa B, while increasing the expression of PPAR gamma and IL-4. Furthermore, we observed higher expression of PPAR gamma and IL-4 and lower expression of TNF-alpha, IFN-gamma and reduced activation of NF-kappa B in suppressive group than those in the therapeutic group, which corresponds to lower clinical score and earlier disease recovery. Our data effectively demonstrate the anti-inflammatory properties of pioglitazone in EAN by inhibition of NF-kappa B signaling pathway.

• 出版日期2012-8
• 单位中南大学