Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates

作者:Boyington Allyson J; Riu Martin Louis Y; Jui Nathan T*
来源:Journal of the American Chemical Society, 2017, 139(19): 6582-6585.
DOI:10.1021/jacs.7b03262

摘要

The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive antiMarkovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.

  • 出版日期2017-5-17