Preparation of C5-substituted O-6,5 '-cyclouridine

作者：Mieczkowski Adam; Peltier Pauline; Zevaco Thomas; Agrofoglio Luigi A^*

来源：Tetrahedron, 2009, 65(20): 4053-4059.

DOI：10.1016/j.tet.2009.02.077

The synthesis of hitherto unknown C5-substituted O-6,5'-cyclouridines is described. The 2',3'-isopropylidene-uridine was treated with N-halogenosuccinimides forming appropriate bridged 5-halogeno derivatives. Using lithiation method, bromine substituent at C5 position was exchanged into various alkyl and alkenyl derivatives.

• 出版日期2009-5-16