A Catalyst-Free Synthetic Route to Thiazolo[3,4-a]benzimidazole Derivatives through a Three-Component Reaction

作者：Alizadeh, Abdolali^*; Bagherinejad, Akram; Moafi, Leila; Zhu, Long-Guan

来源：Synlett, 2016, 27(12): 1803-1805.

DOI：10.1055/s-0035-1561612

• o-phenylenediamine
• aryl isothiocyanate
• 4-chloro-3-oxo-butanoate
• thiazolo[3
• 4-a]benzimidazole
• multicomponent reaction

A convenient approach for the synthesis of thiazolo[3,4-a]-benzimidazole derivatives has been developed. Three-component reaction of readily available o-phenylenediamines, aryl isothiocyanate, and 4-chloro-3-oxobutanoate in toluene-dichloromethane without any catalyst proceeds under reflux to afford the title compounds in high yields. The structure of the target molecule was confirmed by X-ray diffraction.

• 出版日期2016-7
• 单位浙江大学