mRNA 3 ' end processing: A tale of the tail reaches the clinic

作者：Hollerer Ina; Grund Kerstin; Hentze Matthias W^*; Kulozik Andreas E

来源：EMBO Molecular Medicine, 2014, 6(1): 16-26.

DOI：10.1002/emmm.201303300

• control of polyadenylation
• post-transcriptional gene regulation
• clinical importance of 3 ' end mRNA processing
• regulation of 3 ' end mRNA processing

Recent advances reveal mRNA 3 ' end processing as a highly regulated process that fine-tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3 ' end processing, controlling the quality and the quantity of substrate mRNAs. The regulation of 3 ' end processing plays a central role in fundamental physiology such as blood coagulation and innate immunity. In addition, errors in mRNA 3 ' end processing have been associated with a broad spectrum of human diseases, including cancer. We summarize and discuss the paradigmatic shift in the understanding of 3 ' end processing as a mechanism of posttranscriptional gene regulation that has reached clinical medicine.

• 出版日期2014-1