Four new diterpenoid alkaloids from Aconitum japonicum subsp subcuneatum

作者：Yamashita Hiroshi; Takeda Keiko; Haraguchi Machiko; Abe Yuki; Kuwahara Natsumi; Suzuki Shota; Terui Ayaka; Masaka Takumi; Munakata Naoko; Uchida Mariko; Nunokawa Masashi; Kaneda Kyousuke; Goto Masuo; Lee Kuo-Hsiung; Wada Koji^*

来源：Journal of Natural Medicines, 2018, 72(1): 230-237.

DOI：10.1007/s11418-017-1139-9

• Aconitum japonicum subsp subcuneatum
• 14-Anisoyllasianine
• 14-Anisoyl-N-deethylaconine
• N-deethylaljesaconitine A
• N-deethylnevadensine
• Cytotoxicity

Diterpenoid alkaloids with remarkable chemical properties and biological activities are frequently found in plants of the genera Aconitum, Delphinium, and Garrya. Accordingly, several diterpenoid alkaloid constituents of Aconitum and Delphinium plants as well as their derivatives exhibited cytotoxic activity against lung, prostate, nasopharyngeal, and vincristine-resistant nasopharyngeal cancer cell lines. Four new C-19-diterpenoid alkaloids, 14-anisoyllasianine (1), 14-anisoyl-N-deethylaconine (2), N-deethylaljesaconitine A (3), and N-deethylnevadensine (4), together with 17 known C-19- and C-20-diterpenoid alkaloids, were isolated in a phytochemical investigation of rhizoma of Aconitum japonicum Thunb. subsp. subcuneatum (Nakai) Kadota. Their structures were elucidated by extensive spectroscopic methods including NMR (1D and 2D), IR, and MS (HRMS). Eight known diterpenoid alkaloids, lipoaconitine, lipomesaconitine, aconine, nevadenine, talatisamine, nevadensine, ryosenamine, and dehydrolucidusculine, were isolated the first time from A. japonicum subsp. subcuneatum. Three of the new C-19-diterpenoid alkaloids (1, 3, 4) and six of the known diterpenoid alkaloids were evaluated for cytotoxic activity against five human tumor cell lines.

• 出版日期2018-1
• 单位中国医科大学