Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp DT-A37

作者：Ding, Hui; Wang, Jia-Nan; Zhang, Da-Shan; Ma, Zhong-Jun^*

来源：Chemistry and Biodiversity, 2017, 14(9): e1700140.

DOI：10.1002/cbdv.201700140

• Sulfur heterocycles
• Fatty acids
• Biological activities
• Streptomyces sp
• DT-A37
• OSMAC Strategy

On the basis of the one strain-many compounds strategy, five compounds including two new holomycin derivatives 2 - 3, two new cyclopropaneacetic acid derivatives 4 - 5, together with one known compound holomycin (1) were isolated from a marine-derived bacterium Streptomyces sp. DT-A37. Their structures were elucidated using NMR and HR-ESI-MS analyses. All these compounds were evaluated for their antimicrobial activity, cytotoxic activity, and inhibitory activity against BRD4 protein. Compound 1 exhibited potent cytotoxicity against H1975 cells with IC50 value of 1 mu M, and its minimal inhibitory concentration values against Escherichia coli and Staphylococcus aureus were both 64 mu M.

• 出版日期2017-9
• 单位浙江大学