A new, efficient and environmentally benign protocol for the synthesis of 1,5-benzodiazepines using cerium(III) chloride/sodium iodide supported on silica gel

作者：Sabitha G^*; Reddy GSKK; Reddy KB; Reddy NM; Yadav JS

来源：Advanced Synthesis & Catalysis, 2004, 346(8): 921-923.

DOI：10.1002/adsc.200303196

• benzodiazepines
• cerium(III) chloride
• ketones
• Lewis acids
• o-phenylenediamines
• silica gel
• supported catalysts

A novel and green approach has been described for the synthesis of 2,3-dihydro-1H-1,5-benzodiazepines from o-phenylenediamines and ketones using cerium(III) chloride/sodium iodide supported on silica gel under mild and heterogeneous conditions. The reactions are carried out at room temperature without using any organic solvent.

• 出版日期2004-7