Are myelodysplastic syndromes underdiagnosed in Poland? A report by the Polish Adult Leukaemia Group

作者：Drozd Sokolowska Joanna E; Mazdry Krzysztof; Waszczuk Gajda Anna; Zoltak Tomasz; Sikorska Anna; Mital Andrzej; Wajs Jaroslaw; Semenczuk Grazyna; Szmigielska Kaplon Anna; Szczepanska Magdalena; Wasilewska Ewa; Szwedyk Pawel; Holojda Jadwiga; Waztek Marzena; Stella Holowiecka Beata; Soroka Wojtaszko Maria; Homenda Wojciech; Polak Miroslaw; Guzicka Kazimierska Renata; Porowska Agnieszka; Wiktor Jezdrzejczak Wieslaw; Dwilewicz Trojaczek Jadwiga

来源：European Journal of Haematology, 2017, 98(2): 154-159.

DOI：10.1111/ejh.12814

• myelodysplastic syndrome
• incidence
• prevalence

Objectives: The epidemiology of myelodysplastic syndromes (MDS) differs among countries. Here, we present the first epidemiological indices determined for Poland. Methods: Twenty-one haematological centres participated in the study. Patients diagnosed with MDS and acute myeloid leukaemia (AML) with 20-29% blasts were enrolled. Data collection was conducted for strictly predefined period. Results: The overall crude incidence rate for all MDS subtypes was 1.95 (95% CI, 1.81-2.09) per 100 000 person-years: 2.46 (95% CI, 2.24-2.69) for males and 1.47 (95% CI, 1.31-1.65) for females; after excluding AML cases, the indices were as follows: 2.35 (95% CI, 2.08-2.66) for males and 1.27 (95% CI, 1.08-1.5) for females. Prevalence rate was 6.2 per 100 000 persons (95% CI, 5.96-6.45), that is 6.86 (95% CI, 6.49-7.24) for males and 5.58 (95% CI, 5.26-5.92) for females. Both incidence and prevalence increased with increasing age. The most frequently diagnosed MDS subtype was refractory cytopenia with multilineage dysplasia (RCMD), responsible for 30.3% of all newly diagnosed MDSs. Conclusions: RCMD is the most frequent MDS subtype in Poland. Incidence and prevalence indices are lower than those reported for other populations, which probably results from inadequate diagnosis of potential cases of this disease.

• 出版日期2017-2