Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin

作者：Qu Hui Qi^*; Li Quan; Lu Yang; Hanis Craig L; Fisher Hoch Susan P; McCormick Joseph B

来源：Diabetes Care, 2012, 35(12): 2591-2593.

DOI：10.2337/dc12-0636

OBJECTIVE-An elevated insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) is more commonly seen in the Mexican American population than in European populations. We report quantitative ancestral effects within a Mexican American population, and we correlate ancestral components with HOMA-IR. %26lt;br%26gt;RESEARCH DESIGN AND METHODS-We performed ancestral analysis in 1,551 participants of the Cameron County Hispanic Cohort by genotyping 103 ancestry-informative markers (AIMs). These AIMs allow determination of the percentage (0-100%) ancestry from three major continental populations, i.e., European, African, and Amerindian. %26lt;br%26gt;RESULTS-We observed that predominantly Amerindian ancestral components were associated with increased HOMA-IR (beta = 0.124, P = 1.64 X 10(-7)). The correlation was more significant in males (Amerindian beta = 0.165, P = 5.08 X 10(-7)) than in females (Amerindian beta = 0.079, P = 0.019). %26lt;br%26gt;CONCLUSIONS-This unique study design demonstrates how genomic markers for quantitative ancestral information can be used in admixed populations to predict phenotypic traits such as insulin resistance.

• 出版日期2012-12
• 单位McGill