Accumulation of immunoglobulin G against Dermatophagoides farinae tropomyosin in dorsal root ganglia of NC/Nga mice with atopic dermatitis-like symptoms

作者：Otsu Ayaka; Kawasaki Hiroaki; Tominaga Mitsutoshi; Shigenaga Ayako; Matsuda Hironori; Takahashi Nobuaki; Nakajima Tadaaki; Naito Hisashi; Baba Takeshi; Ogawa Hideoki; Tomooka Yasuhiro; Yamakura Fumiyuki^*; Takamori Kenji^*

来源：Biochemical and Biophysical Research Communications, 2017, 485(4): 707-712.

DOI：10.1016/j.bbrc.2017.02.109

• Atopic dermatitis
• Dorsal root ganglia
• IgG
• Itch
• Tropomyosin

Atopic dermatitis (AD), a chronic inflammatory skin disease, manifests as intractable itch, but its underlying mechanisms are poorly understood. This study assessed the relationship between immunoglobulin G (IgG) and dorsal root ganglia (DRG) in NC/Nga mice, a model of AD that manifests AD-like symptoms including itch. Immunohistochemical analysis showed large amounts of IgG in DRG extracts of NC/Nga mice with AD-like dermatitis, with a large fraction of the IgG distributed in satellite glial cells of the DRG. Proteomic analysis showed that this IgG was reactive against tropomyosin of Dermatophagoides farinae. These findings indicate that the accumulation of anti-tropomyosin IgG in DRG of atopic NC/Nga mice may be associated with the pathogenesis of AD-like symptoms, including itch.

• 出版日期2017-4-15