科研之友
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摘要
ObjectivesThis study aimed to examine the possible antecedents of both dementia and sustained intact cognition at age 90years among men who underwent a prospective, multidisciplinary assessment from ages 19 to 90years, with little attrition. MethodsWe conducted a prospective 20-year reassessment of 196 (out of 268) former Harvard college sophomores who survived until age 70years. Since 1939, the study gathered measurements of childhood environment, dominant personality traits, objective mental and physical health over time, smoking in pack-years, alcohol abuse, and depression. Questionnaires were obtained every 2years and physical exams every 5years. Cognitive status was assessed at ages 80, 85, and 90years. ResultsDespite addressing a wide variety of health, behavioral, and social factors over the lifespan, we observed few predictors with strong association with either intact cognition at age 90years (n=40) or dementia (n=44). Univariate analysis revealed seven suggestive predictors of intact cognition at age 90years or of dementia: warm childhood relationship with mother, exercise at age 60years, high maternal education, young age of mother at subject's birth, low body mass index, good physical health at 60years, and late retirement. Only the first three variables, warm childhood relationship with mother, exercise at age 60years, and high maternal education, remained significant with logistic regression. ConclusionsIn this prospective study of long-lived, highly educated men, several well-known putative predictors of Alzheimer's disease did not distinguish those who over the next 20years developed dementia from those with unimpaired cognition until age 90years.
- 出版日期2014-12
