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摘要
This paper demonstrates that the active ingredient in many common tablets (anti-depressives, pain relievers, epileptic medicine and anti-histamines) can be recognized directly and without any pretreatrnent using hot cell membrane inlet mass spectrometry (hot cell MIMS). The tablets were simply placed in a sample vial and then dumped into a small oven heated to approximately 200 degrees C (the hot cell). The hot cell was interfaced directly to the ion source of an electron ionization mass spectrometer (EI-MS) via a polymer membrane. A few minutes thereafter an EI-MS spectrum of the chemicals desorped from the sample was recorded. Even though the tablets contained a significant number of chemicals (fillers) and often a polymer coating in addition to the active ingredients simple EI-MS spectra were recorded, vvherefrom the active ingredient could be recognized by comparison with a standard EI-MS database. Of the eight tablets tested only one tablet, Bio-Melatonin (sleeping disorder), did not give a recognizable EI-MS spectrum. Over a period of 6 months the spectra recorded from the tablets did not change and the active ingredients were always recognized. The reproducibility of signal intensities from characteristic ions following successive injections was high (approximate to 7%) for tablets without surface coating, whereas it varied up to 25% for tablets with a surface coating. Since hot cell MIMS is fully compatible with field portable instruments our results open the possibility of creating a small portable mass spectrometer for use in paramedical vehicles for immediate, on-site identification of medications found near intoxicated patients.
- 出版日期2010-8-1
