Protein degradation and the stress response

作者：Flick Karin^*; Kaiser Peter

来源：Seminars in Cell & Developmental Biology, 2012, 23(5): 515-522.

DOI：10.1016/j.semcdb.2012.01.019

• Ubiquitin ligases
• Stress sensors
• Stress signaling
• Ubiquitin proteasome pathway

Environmental stresses are manifold and so are the responses they elicit. This is particularly true for higher eukaryotes where various tissues and cell types are differentially affected by the insult. Type and scope of the stress response can therefore differ greatly among cell types. Given the importance of the ubiquitin proteasome system (UPS) for most cellular processes, it comes as no surprise that the UPR plays a pivotal role in counteracting the effects of stressors. Here we outline contributions of the UPS to stress sensing, signaling, and response pathways. We make no claim to comprehensiveness but choose selected examples to illustrate concepts and mechanisms by which protein modification with ubiquitin and proteasomal degradation of key regulators ensures cellular integrity during stress situations.

• 出版日期2012-7