Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing

作者:Ku Ti Hsuan; Zhang Tiantian; Luo Hua; Yen Tony M; Chen Ping Wei; Han Yuanyuan; Lo Yu Hwa
来源:Sensors (Switzerland), 2015, 15(7): 16281-16313.
DOI:10.3390/s150716281

摘要

Detection of small molecules or proteins of living cells provides an exceptional opportunity to study genetic variations and functions, cellular behaviors, and various diseases including cancer and microbial infections. Our aim in this review is to give an overview of selected research activities related to nucleic acid-based aptamer techniques that have been reported in the past two decades. Limitations of aptamers and possible approaches to overcome these limitations are also discussed.