Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

作者：Kitajima Mariko; Iwai Masumi; Kikura Hanajiri Ruri; Goda Yukihiro; Iida Mitsuru; Yabushita Hisatoshi; Takayama Hiromitsu^*

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(7): 1962-1964.

DOI：10.1016/j.bmcl.2011.02.036

• Cannabinoid
• CB1 receptor
• Antagonist
• Indole alkaloid
• Iboga
• Voacanga

Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids.

• 出版日期2011-4-1