4,5-Dicyanoimidazole-promoted synthesis of dinucleoside polyphosphates and their analogs

作者：Sun, Qi^*; Gong, Shan-Shan; Liu, Si; Sun, Jian; Liu, Guo-Dong; Ma, Cha

来源：Tetrahedron, 2014, 70(30): 4500-4506.

DOI：10.1016/j.tet.2014.05.013

• Dinucleoside diphosphate
• Dinucleoside triphosphate
• Dinucleoside tetraphosphate
• Phosphoropiperidate
• 4,5-Dicyanoimidazole

A general and efficient P(V)-N activation method for the preparation of symmetrical and asymmetrical dinucleoside polyphosphates (NpnN's, n=2-4) and P-2,P-3-CX2-dinucleoside tetraphosphates (X=H, F, and Cl) has been established. Twenty-two dinucleoside polyphosphates and their phosphonate analogs were synthesized from nucleoside 5'-phosphoropiperidates with 4,5-dicyanoimidazole as the activator in good to high yields.

• 出版日期2014-7-29
• 单位江西科技师范大学