A Randomized, Controlled Trial of Levonorgestrel Vs. The Yuzpe Regimen as Emergency Contraception Method among Iranian Women

作者：Hoseini Fatemeh Sadat^*; Eslami Mohammad; Abbasi Mohammad; Fashkhami Fatemeh Noroozi; Besharati Soheila

来源：Iranian Journal of Public Health (English Ed.), 2013, 42(10): 1158-1166.

• Levonorgestrel
• Yuzpe regimen
• Emergency contraception
• Side-effects

Background: We aimed to compare acceptability of Levonorgestrel with the Yuzpe regimen among Iranian women based on their side-effects and resulting changes in the amount and pattern of menses. %26lt;br%26gt;Methods: Five hundred twenty nine participants aged 15-49 having regular menses and one act of unprotected intercourse within 72 h were included in the double-blind, controlled trial in 2006-2007 and randomly assigned into LNG (n=263) and HD (n=266) groups, receiving Levonorgestrel 0.75 mg given 12 h apart and ethinyl estradiol 100 mu g plus 0.5 mg Levonorgestrel 0.5 mg repeated after 12 h, respectively. %26lt;br%26gt;Results: The participants receiving Levonorgestrel experienced significantly lower side-effects in the case of nausea, vomiting, and dizziness (P%26lt;0.05). The changes occurred in the amount and pattern of menses were the same for both groups (P%26gt;0.05). No significant difference was observed between the efficiencies of the treatments. %26lt;br%26gt;Conclusion: Significantly lower side-effects of Levonorgestrel can be considered as greater acceptability and translated to higher efficiency.

• 出版日期2013-10