Accumulation of major histocompatibility complex class II+CD11c non-lymphoid cells in the spleen during infection with Plasmodium yoelii is lymphocyte-dependent

作者：Kamei Rika; Miyakoda Mana; Tamura Takahiko; Kimura Daisuke; Honma Kiri; Kimura Kazumi; Yui Katsuyuki^*

来源：Microbiology and Immunology, 2013, 57(3): 213-223.

DOI：10.1111/1348-0421.12024

• inflammation
• lymphocytes
• major histocompatibility complex
• malaria

The spleen is the main organ for immune defense during infection with Plasmodium parasites and splenomegaly is one of the major symptoms of such infections. Using a rodent model of Plasmodium yoelii infection, MHC class II+CD11c non-T, non-B cells in the spleen were characterized. Although the proportion of conventional dendritic cells was reduced, that of MHC II+CD11c non-T, non-B cells increased during the course of infection. The increase in this subpopulation was dependent on the presence of lymphocytes. Experiments using Rag-2/ mice with adoptively transferred normal spleen cells indicated that these cells were non-lymphoid cells; however, their accumulation in the spleen during infection with P. yoelii depended on lymphocytes. Functionally, these MHC II+CD11c non-T, non-B cells were able to produce the proinflammatory cytokines alpha tumor necrosis factor and interleukin-6 in response to infected red blood cells, but had only a limited ability to activate antigen-specific CD4+ T cells. This study revealed a novel interaction between MHC II+CD11c non-lymphoid cells and lymphoid cells in the accumulations of these non-lymphoid cells in the spleen during infection with P. yoelii.

• 出版日期2013-3