A novel polymer-free drug-eluting stent coated with everolimus using nitrogen-doped titanium dioxide film deposition in a porcine coronary restenosis model

作者：Sim Doo Sun; Jeong Myung Ho; Park Dae Sung; Kim Jung Ha; Lim Kyung Seob; Bae In Ho; Zhehao Piao; Yang Hae Young; Lee Je Hoon; Hyun Dae Young; Hong Young Joon; Kim Ju Han; Ahn Youngkeun; Kang Jung Chaee

来源：International Journal of Cardiology, 2016, 222: 436-440.

DOI：10.1016/j.ijcard.2016.07.275

• Drug-eluting stents
• Titanium dioxide
• Polymers

Background: Titanium dioxide (TiO2) films have superior biocompatibility and may be effective as drug-binding matrices for drug-eluting stents (DESs). We sought to evaluate efficacy of a polymer-free DES coatedwith everolimus using nitrogen-doped TiO2 film deposition in a porcine coronary restenosis model.
Methods: Forty coronary arteries in 20 pigs were randomly allocated to group 1 (bare-metal stents (BMSs), 3.0 x 18 mm, n = 10), group 2 (BMSs with nitrogen-doped TiO2 film deposition, 3.0 x 18 mm, n = 10), group 3 [commercial everolimus-eluting stent, 3.0 x 18 mm, n = 10], and group 4 (polymer-free everolimus-eluting stent using nitrogen-doped TiO2 film deposition, 3.0 x 18 mm, n = 10). Stents were randomly implanted in the left anterior descending coronary artery and left circumflex artery with stentiartery ratio of 1.3. Four weeks later, pigs underwent follow-up coronary angiography and were sacrificed for histopathologic analysis.
Results: Percent area stenosis was greater in group 1 compared to groups 3 and 4 (46.4 +/- 13.8% vs. 30.2 +/- 11.7% vs. 29.2 +/- 8.9%, respectively, p = 0.005). Fibrin score was lower in groups 1 and 2, compared to groups 3 and 4: 0.87 +/- 0.67 vs. 0.76 +/- 0.61 vs. 2.27 +/- 0.24 vs. 1.75 +/- 0.31, respectively, p < 0.001). Injury score and inflammation score were not different. Comparison between DES showed a higher fibrin score in group 3 than group 4 (2.27 +/- 0.24 vs. 1.75 +/- 0.31, p = 0.023).
Conclusions: In a porcine model of coronary restenosis, a novel polymer-free DES using nitrogen-doped TiO2 film deposition shows higher biocompatibility and compares favorably with a commercial DES.

• 出版日期2016-11-1