Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative disease

作者：Jonsson Viggo^*; Tjonnfjord Geir; Samuelsen Sven Ove; Johannesen Tom; Olsen Jorgen; Sellick Gabrielle; Houlston Richard; Yuille Martin; Catovsky Daniel

来源：Leukemia and Lymphoma, 2007, 48(12): 2387-2396.

DOI：10.1080/10428190701686273

• chronic lymphocytic leukaemia
• non-Hodgkin's lymphoma
• lymphoproliferative disorders
• birth-order effect
• imprinting
• microchimerism

Rank order of affected offspring in a sibship can inform on epigenetic factors in disease susceptibility. Here we report an analysis of birth order in 32 families segregating chronic lymphocytic leukaemia (CLL) and other B-cell lymphoproliferative disorders. A paternal-offspring, but not a maternal-offspring birth rank order was observed. Cox regression analysis provided relative risks (RR) for paternal and maternal transmission of 3.60 (CI 95%: 1.54-8.42; P = 0.0005) and 1.64 (CI 95%: 0.90-3.01; P = 0.096), respectively. The significance of paternal and maternal transmission of CLL-CLL pairs employing Haldane and Smith's test were 0.006 and 0.63, respectively. There was no evidence of a relationship between parental age and birth order. The genetic mechanism behind the birth order effect observed is discussed in the light of non-Mendelian imprinting and pregnancy related microchimerism.

• 出版日期2007