Designing a sequential Ugi/Ullmann type reaction for the synthesis of indolo[1,2-a]quinoxalinones catalyzed by CuI/L-proline

作者：Balalaie Saeed^*; Bararjanian Morteza; Hosseinzadeh Saeedeh; Rominger Frank; Bijanzadeh Hamid Reza; Wolf Eckardt

来源：Tetrahedron, 2011, 67(38): 7294-7300.

DOI：10.1016/j.tet.2011.07.052

• Indolo[1,2-a]quinoxalinones
• CuI/t-Proline catalyst
• Ugi reaction
• Ullmann reaction
• One-pot procedure

An efficient strategy for the one-pot syntheses of indolo[1,2-a]quinoxalinones catalyzed by CuI have been developed. The procedures combine the Ugi four-component reaction of aldehydes, 2-iodoaniline, 2-indole carboxylic acid, and isocyanides followed by the copper-catalyzed intramolecular N-arylation of the Ugi product in one-pot procedure, which afford the desired products in good to very good yields.

• 出版日期2011-9-23