Automated volumetric evaluation of stereoscopic disc photography

作者：Xu Juan^*; Ishikawa Hiroshi; Wollstein Gadi; Bilonick Richard A; Kagemann Larry; Craig Jamie E; Mackey David A; Hewitt Alex W; Schuman Joel S

来源：Optics Express, 2010, 18(11): 11347-11359.

DOI：10.1364/OE.18.011347

PURPOSE: To develop a fully automated algorithm (AP) to perform a volumetric measure of the optic disc using conventional stereoscopic optic nerve head (ONH) photographs, and to compare algorithm-produced parameters with manual photogrammetry (MP), scanning laser ophthalmoscope (SLO) and optical coherence tomography (OCT) measurements. METHODS: One hundred twenty-two stereoscopic optic disc photographs (61 subjects) were analyzed. Disc area, rim area, cup area, cup/disc area ratio, vertical cup/disc ratio, rim volume and cup volume were automatically computed by the algorithm. Latent variable measurement error models were used to assess measurement reproducibility for the four techniques. RESULTS: AP had better reproducibility for disc area and cup volume and worse reproducibility for cup/disc area ratio and vertical cup/disc ratio, when the measurements were compared to the MP, SLO and OCT methods. CONCLUSION: AP provides a useful technique for an objective quantitative assessment of 3D ONH structures.

• 出版日期2010-5-24