Decorosides A and B, Cytotoxic Flavonoid Glycosides from the Leaves of Rhododendron decorum

作者：Rateb Mostafa E^*; Hassan Hossam M; Arafa El Shaimaa A; Jaspars Marcel; Ebel Rainer

来源：Natural Product Communications, 2014, 9(4): 473-476.

DOI：10.1177/1934578x1400900410

• Rhododendron decorum
• Decoroside
• Flavonoid
• Cytotoxic activities

Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1 -%26gt; 6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

• 出版日期2014-4